0604国际期刊速递丨今日热点巨噬细

　北京中科白癜风医院热心公益 https://m-mip.39.net/disease/mipso_5496904.html
TODAY今日发布JournalofCardiacSurgeryEarlyRecent,June03,今日发布01篇TheLancetEarlyRecent,June03,今日发布01篇Neuromodulation:TechnologyattheNeuralInterfaceEarlyRecent,June03,今日发布01篇JournalofClinicalUltrasoundEarlyRecent,June03,今日发布02篇TheJournalofClinicalHypertensionEarlyRecent,June03,今日发布01篇JAMAEarlyRecent,June03,今日发布07篇JAMACardiologyEarlyRecent,June03,今日发布05篇CircGenomPrecisMedEarlyRecent,June03,今日发布01篇NEJMJune04,:(23)今日发布27篇CLINPHYSIOLFUNCTIJuly01,:40(4),i-iii,今日发布12篇JCARDIOVASCELECTREarlyRecent,June04,今日发布01篇CirculationEarlyRecent,June04,今日发布01篇ATVBEarlyRecent,June04,今日发布05篇CirculationResearchEarlyRecent,June04,今日发布02篇RECOMMEND推荐阅读01巨噬细胞（Drp1）动态蛋白1促进血管损伤后内膜增厚ATVBresearch-articleRyutaUmezu,Jun-ichiroKoga,etc.2小时前等13用户推荐阅读本文Objective:Mitochondriaconsistentlychangetheirmorphologyinaprocessregulatedbyproteins,includingDrp1(dynamin-relatedprotein1),aproteinpromotingmitochondrialfission.Drp1isinvolvedinthemechanismsunderlyingvariouscardiovasculardiseases,suchasmyocardialischemia/reperfusioninjury,heartfailure,andpulmonaryarterialhypertension.However,itsroleinmacrophages,whichpromotevariousvasculardiseases,ispoorlyunderstood.WethereforetestedourhypothesisthatmacrophageDrp1promotesvascularremodelingafterinjury.线粒体在蛋白质调控的过程中不断改变其形态，包括Drp1（动态蛋白相关蛋白1），一种促进线粒体分裂的蛋白质。Drp1参与多种心血管疾病的发病机制，如心肌缺血/再灌注损伤、心力衰竭和肺动脉高压。然而，它在促进各种血管疾病的巨噬细胞中的作用还不清楚。因此，我们验证了巨噬细胞Drp1促进损伤后血管重塑的假说。MethodandResults:ToexploretheselectiveroleofmacrophageDrp1,wecreatedmacrophage-selectiveDrp1-deficientmiceandperformedfemoralarterialwireinjury.Inthesemice,intimalthickeningandnegativeremodelingwereattenuatedat4weeksafterinjurywhen

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